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Behav Brain Res. 2018 Sep 17;350:72-79. doi: 10.1016/j.bbr.2018.05.012. Epub 2018 May 17.

Impaired spatial processing in a mouse model of fragile X syndrome.

Author information

1
Graduate Program in Neuroscience, University of Victoria, Victoria, BC, Canada; Division of Medical Sciences, University of Victoria, Victoria, BC, Canada.
2
Division of Medical Sciences, University of Victoria, Victoria, BC, Canada.
3
Division of Medical Sciences, University of Victoria, Victoria, BC, Canada; Island Medical Program, University of British Columbia, Victoria, BC, Canada. Electronic address: jgil@uvic.ca.
4
Graduate Program in Neuroscience, University of Victoria, Victoria, BC, Canada; Division of Medical Sciences, University of Victoria, Victoria, BC, Canada; Island Medical Program, University of British Columbia, Victoria, BC, Canada.

Abstract

Fragile X syndrome (FXS) is the most common form of inherited intellectual impairment. The Fmr1-/y mouse model has been previously shown to have deficits in context discrimination tasks but not in the elevated plus-maze. To further characterize this FXS mouse model and determine whether hippocampal-mediated behaviours are affected in these mice, dentate gyrus (DG)-dependent spatial processing and Cornu ammonis 1 (CA1)-dependent temporal order discrimination tasks were evaluated. In agreement with previous findings of long-term potentiation deficits in the DG of this transgenic model of FXS, the results reported here demonstrate that Fmr1-/y mice perform poorly in the DG-dependent metric change spatial processing task. However, Fmr1-/y mice did not present deficits in the CA1-dependent temporal order discrimination task, and were able to remember the order in which objects were presented to them to the same extent as their wild-type littermate controls. These data suggest that the previously reported subregional-specific differences in hippocampal synaptic plasticity observed in the Fmr1-/y mouse model may manifest as selective behavioural deficits in hippocampal-dependent tasks.

KEYWORDS:

Cornu ammonis 1; Dentate gyrus; Fmr1(−/y) mouse; Fragile X syndrome; Hippocampus; Metric change; Temporal order

PMID:
29778627
DOI:
10.1016/j.bbr.2018.05.012
[Indexed for MEDLINE]

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