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Sci Rep. 2018 May 18;8(1):7864. doi: 10.1038/s41598-018-26198-7.

Stretching Reduces Tumor Growth in a Mouse Breast Cancer Model.

Author information

1
Osher Center for Integrative Medicine, Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
2
Dana Farber Cancer Institute, Institute, Department of Cancer Biology, Boston, USA.
3
Harvard Medical School Department of Biological Chemistry and Molecular Pharmacology, Boston, USA.
4
University of Vermont Department of Medical Biostatistics, Burlington, USA.
5
University of Vermont Cancer Center, Burlington, USA.
6
Dana Farber Cancer Institute, Institute, Department of Cancer Biology, Boston, USA. Jean_zhao@dfci.harvard.edu.
7
Harvard Medical School Department of Biological Chemistry and Molecular Pharmacology, Boston, USA. Jean_zhao@dfci.harvard.edu.
8
Osher Center for Integrative Medicine, Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA. hlangevin@bwh.harvard.edu.

Abstract

There is growing interest in developing non-pharmacological treatments that could boost natural defenses against cancer and contribute to primary and secondary cancer prevention. Recent studies have shown that gentle daily stretching for 10 minutes can reduce local connective tissue inflammation and fibrosis. Because mechanical factors within the stroma can influence the tumor microenvironment, we hypothesized that stretching would reduce the growth of tumors implanted within locally stretched tissues and tested this hypothesis in a mouse orthotopic breast cancer model. Female FVB mice (N = 66) underwent bilateral injection of p53/PTEN double-null primary mouse mammary tumor cells into the third mammary fat pad. Mice were randomized to stretch vs. no stretch, and treated for 10 minutes once a day, for four weeks. Tumor volume at end-point was 52% smaller in the stretch group, compared to the no-stretch group (p < 0.001) in the absence of any other treatment. Cytotoxic immune responses were activated and levels of Specialized Pro-Resolving Mediators were elevated in the stretch group. These results suggest a link between immune exhaustion, inflammation resolution and tumor growth. Stretching is a gentle, non-pharmacological intervention that could become an important component of cancer treatment and prevention.

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