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Osteoarthritis Cartilage. 2018 Aug;26(8):1055-1062. doi: 10.1016/j.joca.2018.05.008. Epub 2018 May 25.

Association of childhood adiposity measures with adulthood knee cartilage defects and bone marrow lesions: a 25-year cohort study.

Author information

1
Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia. Electronic address: tao.meng@utas.edu.au.
2
Department of Radiology, Royal Hobart Hospital, Hobart, Australia. Electronic address: shuan.thayer@ths.tas.gov.au.
3
Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia. Electronic address: alison.venn@utas.edu.au.
4
Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia. Electronic address: feitong.wu@utas.edu.au.
5
Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia. Electronic address: flavia.cicuttini@monash.edu.
6
Institute of Bone and Joint Research, University of Sydney, Sydney, Australia. Electronic address: lyn.march@sydney.edu.au.
7
Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia; The George Institute for Global Health, Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Oxford, United Kingdom. Electronic address: terry.dwyer@mcri.edu.au.
8
Department of Radiology, Royal Hobart Hospital, Hobart, Australia. Electronic address: andrewhalliday@hotmail.com.
9
Institute of Bone and Joint Research, University of Sydney, Sydney, Australia. Electronic address: maritac@med.usyd.edu.au.
10
Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia. Electronic address: laura.laslett@utas.edu.au.
11
Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia. Electronic address: graeme.jones@utas.edu.au.
12
Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia; Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic address: Changhai.Ding@utas.edu.au.
13
Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia. Electronic address: benny.eathakkattuantony@utas.edu.au.

Abstract

OBJECTIVE:

To describe the associations between childhood adiposity measures and adulthood knee cartilage defects and bone marrow lesions (BMLs) measured 25 years later.

METHODS:

327 participants from the Australian Schools Health and Fitness Survey (ASHFS) of 1985 (aged 7-15 years) were followed up 25 years later (aged 31-41 years). Childhood measures (weight, height and skinfolds) were collected in 1985. Body mass index (BMI), overweight status and fat mass were calculated. Participants underwent 1.5 T knee magnetic resonance imaging (MRI) during 2008-2010, and cartilage defects and BMLs were scored from knee MRI scans. Log binomial regressions were used to examine the associations.

RESULTS:

Among 327 participants (47.1% females), 21 (6.4%) were overweight in childhood. Childhood adiposity measures were associated with the increased risk of adulthood patellar cartilage defects (Weight relative risk (RR) 1.05/kg, 95% confidence interval (CI) 1.01-1.09; BMI 1.10/kg/m2, 1.01-1.19; Overweight 2.22/yes, 1.21-4.08; fat mass 1.11/kg, 1.01-1.22), but not tibiofemoral cartilage defects. Childhood adiposity measures were not significantly associated with adulthood knee BMLs except for the association between childhood overweight status and adulthood patellar BMLs (RR 2.87/yes, 95% CI 1.10-7.53). These significant associations persisted after adjustment for corresponding adulthood adiposity measure.

CONCLUSION:

Childhood adiposity measures were associated with the increased risk of adulthood patellar cartilage defects and, to a lesser extent, BMLs, independent of adulthood adiposity measures. These results suggest that adiposity in childhood has long-term effects on patellar structural abnormalities in young adults.

KEYWORDS:

Adiposity; Bone marrow lesions; Cartilage defects; Childhood

PMID:
29775733
DOI:
10.1016/j.joca.2018.05.008
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