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Int J Biol Macromol. 2018 Sep;116:911-919. doi: 10.1016/j.ijbiomac.2018.05.092. Epub 2018 May 29.

Dual pH-sensitive supramolecular micelles from star-shaped PDMAEMA based on β-cyclodextrin for drug release.

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College of Chemistry and Materials Science, Ludong University, Yantai 264025, China.
College of Chemistry, Sichuan University, Chengdu 610064, China.
College of Chemistry and Materials Science, Ludong University, Yantai 264025, China. Electronic address:


Star-shaped poly(2-(dimethylamino)ethyl methacrylate) based on β-cyclodextrin (β-CD-(PDMAEMA)7) was synthesized by means of atomic transfer radical polymerization (ATRP). Dual pH-sensitive supramolecular micelles were formed from β-CD-(PDMAEMA)7 and benzimidazole modified poly(ε-caprolactone) (BM-PCL) through the host-guest interactions between β-CD and benzimidazole. The supramolecular micelles have regular spherical structure with hydrophobic β-CD/BM-PCL as the core and pH-sensitive PDMAEMA as the shell. The hydrophobic PCL as well as the hydrophobic cavity of β-CD can efficiently encapsulate doxorubicin (DOX) with the drug-loading content and entrapment efficiency up to 40% and 86%. The drug release from micelles accelerated when the pH decreased from 7.0 to 2.0 and the temperature increased from 25 °C to 45 °C. MTT assay showed that drug loaded supramolecular micelles exhibited excellent anti-cancer activity than free DOX. These supramolecular micelles have promising potential applications as intelligent nanocarriers in drug delivery system.


Star-shaped poly(2-(dimethylamino)ethyl methacrylate); Supramolecular micelles; β-cyclodextrin

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