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Int J Antimicrob Agents. 2018 Nov;52(5):673-677. doi: 10.1016/j.ijantimicag.2018.05.007. Epub 2018 Oct 8.

The comparative efficacy of antiseptics against Candida auris biofilms.

Author information

1
School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK; Institute of Healthcare, Policy and Practice, School of Health, Nursing and Midwifery, University of the West of Scotland, Paisley, UK.
2
School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
3
Microbiology Department, Glasgow Royal Infirmary, NHS Greater Glasgow and Clyde, Glasgow, UK.
4
Institute of Healthcare, Policy and Practice, School of Health, Nursing and Midwifery, University of the West of Scotland, Paisley, UK.
5
School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. Electronic address: gordon.ramage@glasgow.ac.uk.

Abstract

Candida auris has emerged as a significant clinical entity as it can cause outbreaks within the healthcare setting. A key feature of its nosocomial properties is that it can transfer between patients, yet little is known about the mechanisms behind this. A panel of C. auris clinical isolates were screened for their planktonic and sessile susceptibilities to skin disinfection challenge using povidone iodine, chlorhexidine and hydrogen peroxide. C. auris biofilms displayed increased tolerance to these strategies compared with planktonic cells. Additionally, analysis using a complex biofilm model demonstrated reduced susceptibility against clinically-relevant concentrations of chlorhexidine and hydrogen peroxide, with eradication achieved only using povidone iodine. Principal component analysis (PCA) also revealed distinct clustering of C. auris biofilms compared with C. albicans and C. glabrata biofilms, and directionality with respect to different treatments. These findings indicate differential responses of different Candida species with respect to antiseptic challenge against biofilms, with C. auris appearing to be more resilient as a complex community.

KEYWORDS:

Antiseptics; Biofilm; Candida auris; Decolonization; Resistance

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