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Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2018 Apr 28;43(4):457-460. doi: 10.11817/j.issn.1672-7347.2018.04.020.

[Evaluation of inflammatory activity in thyroid associated ophthalmopathy by SPECT/CT with 99mTc-DTPA].

[Article in Chinese; Abstract available in Chinese from the publisher]

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Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha 410008, China.
Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.


in English, Chinese

To evaluate the inflammatory activity in thyroid associated ophthalmopathy (TAO) by 99mTc-diethylene triamine pentaaceticacid (99mTc-DTPA) orbital single-photon emission computed tomography (SPECT)/CT.
 Methods: A total of 48 patients were enrolled from Xiangya Hospital of Central South University between October 2016 and March 2017. According to clinical active score (CAS), 93 eyes were divided into a TAO active group (n=72) and a TAO inactive group (n=21). All patients underwent 99mTc-DTPA orbital SPECT/CT examination, and the DTPA uptake in extraocular muscle belly was supposed to be positive. The results of 99mTc-DTPA orbital SPECT/CT examination were compared with those of CAS score evaluation.
 Results: The uptake rate (UR) of 99mTc-DTPA in the TAO active group was higher than that in the TAO inactive group (P<0.01). There was a linear positive correlation between UR and its CAS scores in all patients (r=0.767, P<0.01). Five cases (7 eyes) showed inconsistent results between 99mTc-DTPA orbital SPECT/CT examination and CAS score. Among the 7 eyes, 6 eyes showed myocarditis lesions in 99mTc-DTPA orbital SPECT/CT examination while its CAS was no more than 3; meanwhile, there was 1 eye with CAS>3, but 99mTc-DTPA orbital SPECT/CT examination showed negative myocarditis lesions.
 Conclusion: 99mTc-DTPA orbital SPECT/CT is consistent with the CAS score in evaluation of the disease activity of TAO; 99mTc-DTPA orbital SPECT/CT may be more objective and accurate to evaluate TAO than CAS.

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