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Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2018 Apr 28;43(4):457-460. doi: 10.11817/j.issn.1672-7347.2018.04.020.

[Evaluation of inflammatory activity in thyroid associated ophthalmopathy by SPECT/CT with 99mTc-DTPA].

[Article in Chinese; Abstract available in Chinese from the publisher]

Author information

1
Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha 410008, China.
2
Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.

Abstract

in English, Chinese

To evaluate the inflammatory activity in thyroid associated ophthalmopathy (TAO) by 99mTc-diethylene triamine pentaaceticacid (99mTc-DTPA) orbital single-photon emission computed tomography (SPECT)/CT.
 Methods: A total of 48 patients were enrolled from Xiangya Hospital of Central South University between October 2016 and March 2017. According to clinical active score (CAS), 93 eyes were divided into a TAO active group (n=72) and a TAO inactive group (n=21). All patients underwent 99mTc-DTPA orbital SPECT/CT examination, and the DTPA uptake in extraocular muscle belly was supposed to be positive. The results of 99mTc-DTPA orbital SPECT/CT examination were compared with those of CAS score evaluation.
 Results: The uptake rate (UR) of 99mTc-DTPA in the TAO active group was higher than that in the TAO inactive group (P<0.01). There was a linear positive correlation between UR and its CAS scores in all patients (r=0.767, P<0.01). Five cases (7 eyes) showed inconsistent results between 99mTc-DTPA orbital SPECT/CT examination and CAS score. Among the 7 eyes, 6 eyes showed myocarditis lesions in 99mTc-DTPA orbital SPECT/CT examination while its CAS was no more than 3; meanwhile, there was 1 eye with CAS>3, but 99mTc-DTPA orbital SPECT/CT examination showed negative myocarditis lesions.
 Conclusion: 99mTc-DTPA orbital SPECT/CT is consistent with the CAS score in evaluation of the disease activity of TAO; 99mTc-DTPA orbital SPECT/CT may be more objective and accurate to evaluate TAO than CAS.

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