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Support Care Cancer. 2018 Nov;26(11):3801-3809. doi: 10.1007/s00520-018-4247-5. Epub 2018 May 17.

Neuropsychological profiles of breast cancer and brain tumor cohorts in Northeast Ontario, Canada.

Author information

1
Supportive Care Oncology Research Unit, Supportive Care Unit, Northeast Cancer Centre, Health Sciences North, 41 Ramsey Lake Road, Sudbury, ON, P3E 5J1, Canada. dr.mariani@bell.net.
2
Mariani and Associates, 208 Caswell Dr., Sudbury, ON, P3E 2N8, Canada. dr.mariani@bell.net.
3
Supportive Care Oncology Research Unit, Supportive Care Unit, Northeast Cancer Centre, Health Sciences North, 41 Ramsey Lake Road, Sudbury, ON, P3E 5J1, Canada.

Abstract

PURPOSE:

As developments in cancer treatment have improved outcomes, research has increasingly focused on the role of cancer-related cognitive impairment (CRCI) in quality of life for cancer survivors. Impairment profiles have been heterogeneous across studies, necessitating the study of these effects across different cohorts. The purpose of this preliminary study is to compare the memory profiles of Northeast Ontario breast and CNS cancer patients, as there is no literature which exists for profiling CRCI within this largely rural region.

METHODS:

Sixty-three outpatients with breast cancer (nā€‰=ā€‰32) or CNS tumors (nā€‰=ā€‰30) at the Northeast Cancer Centre in Sudbury, Canada, were administered a neuropsychological test battery as part of their clinical examination. Domains measured within this study included attention and concentration, processing speed, motor function, language skills, verbal and visual memory, and executive functioning.

RESULTS:

Participants with brain tumors scored poorer on most neuropsychological measures than participants with breast cancer. Initial verbal memory for individuals with breast cancer was lower than delayed recall and recognition trials. Trial 1 performance for this group was also negatively correlated with self-reported anxiety scores.

CONCLUSIONS:

Consistent with the literature, participants with breast cancer obtained higher scores on most test measures than participants with CNC tumors. Breast cancer participants had lower verbal memory scores on initial trials compared to delayed recall, potentially due to relationships with anxiety and attention. Further research into this cohort will strive to gain greater understanding of the patterns of deficits experienced and how these may inform individuals with cancer in other regions.

KEYWORDS:

Brain tumor; Breast cancer; Cancer; Cognition; Memory; Neuropsychology

PMID:
29774475
DOI:
10.1007/s00520-018-4247-5
[Indexed for MEDLINE]

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