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Nat Commun. 2018 May 17;9(1):1980. doi: 10.1038/s41467-018-04379-2.

MxB is an interferon-induced restriction factor of human herpesviruses.

Author information

1
Institute of Medical Virology, University of Zurich, Winterthurerstrasse 190, 8057, Zürich, Switzerland.
2
Life Science Zurich Graduate School, Winterthurerstrasse 190, 8057, Zürich, Switzerland.
3
Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057, Zürich, Switzerland.
4
Institute of Experimental Immunology, University of Zurich, Winterthurerstrasse 190, 8057, Zürich, Switzerland.
5
Institute of Virology, University of Zurich, Winterthurerstrasse 266a, 8057, Zürich, Switzerland.
6
Department of Neurosurgery and Neuropathology, University Hospital Zurich, Frauenklinikstrasse 10, 8091, Zürich, Switzerland.
7
Institute of Medical Virology, University of Zurich, Winterthurerstrasse 190, 8057, Zürich, Switzerland. pavlovic.jovan@virology.uzh.ch.

Abstract

The type I interferon (IFN) system plays an important role in controlling herpesvirus infections, but it is unclear which IFN-mediated effectors interfere with herpesvirus replication. Here we report that human myxovirus resistance protein B (MxB, also designated Mx2) is a potent human herpesvirus restriction factor in the context of IFN. We demonstrate that ectopic MxB expression restricts a range of herpesviruses from the Alphaherpesvirinae and Gammaherpesvirinae, including herpes simplex virus 1 and 2 (HSV-1 and HSV-2), and Kaposi's sarcoma-associated herpesvirus (KSHV). MxB restriction of HSV-1 and HSV-2 requires GTPase function, in contrast to restriction of lentiviruses. MxB inhibits the delivery of incoming HSV-1 DNA to the nucleus and the appearance of empty capsids, but not the capsid delivery to the cytoplasm or tegument dissociation from the capsid. Our study identifies MxB as a potent pan-herpesvirus restriction factor which blocks the uncoating of viral DNA from the incoming viral capsid.

PMID:
29773792
PMCID:
PMC5958057
DOI:
10.1038/s41467-018-04379-2
[Indexed for MEDLINE]
Free PMC Article

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