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Sleep Med. 2018 Jun;46:56-60. doi: 10.1016/j.sleep.2018.01.014. Epub 2018 Mar 22.

Associations between REV-ERBα, sleep duration and body mass index in European adolescents.

Author information

1
Youth/Child Cardiovascular Risk and Environmental (YCARE) Research Group, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil; Growth, Exercise, Nutrition and Development (GENUD) Research Group, Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria Aragón (IIS Aragón), Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn), Universidad de Zaragoza, Zaragoza, Spain. Electronic address: marcus1986@usp.br.
2
Inserm, Institut Pasteur de Lille, Univ. Lille, UMR1167-RID-AGE-Risk factors and molecular determinants of aging-related diseases, F-59000 Lille, France.
3
Youth/Child Cardiovascular Risk and Environmental (YCARE) Research Group, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
4
Youth/Child Cardiovascular Risk and Environmental (YCARE) Research Group, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil; Bloomberg School of Public Health, Department of Epidemiology, John Hopkins University, USA.
5
Growth, Exercise, Nutrition and Development (GENUD) Research Group, Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria Aragón (IIS Aragón), Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn), Universidad de Zaragoza, Zaragoza, Spain.
6
Preventive Medicine and Nutrition Unit, University of Crete School of Medicine, Heraklion, Crete, Greece.
7
Department of Pediatrics, Medical Faculty, University of Pecs, Pecs, Hungary.
8
Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
9
Department of Public Health, Faculty of Medicine and Health Sciences, Ghent University, Belgium.
10
Department of Physiology, School of Medicine, University of Granada, Granada, Spain.
11
CREA Research Centre for Food and Nutrition, Rome, Italy.
12
Immunonutrition Research Group, Department of Metabolism and Nutrition, Food Science and Technology and Nutrition Institute, Spanish National Research Council, Madrid, Spain.
13
Department of Pediatrics, Private Medical University Salzburg, Salzburg, Austria.
14
Inserm U995, Universite Lille 2, Lille, France.
15
Institut fur Ernahrungs-und Lebensmittelwissenschaften-Humanernahrung, Rheinische Friedrich-Wilhelms-Universitat Bonn, Bonn, Germany; Department of Health and Human Performance, Faculty of Physical Activity and Sport-INEF, Technical University of Madrid, Madrid, Spain.

Abstract

BACKGROUND/OBJECTIVE:

Although the REV-ERBα is considered an important regulator of both clock function and metabolism, its relationship with sleep duration and obesity is less clear. The objective of this study was to examine the association between the REV-ERBα clock gene and two outcomes - sleep duration and body mass index (BMI) - in European adolescents.

METHODS:

A sample of 831 adolescents (392 boys) aged 11.5-18.8 years from 10 European centers was used. The independent variables were REV-ERBα rs2071427 and rs2071570 SNPs, and their respective haplotypes. The outcomes were sleep duration and BMI.

RESULTS:

In girls, no significant association were found between rs2071427 or rs2071570 and the studied outcomes (p ≥ 0.43). In boys, however, significant associations were found between rs2071570 and sleep duration (β: -0.32 h/day for T minor allele carriers; p = 0.0017), and rs2071427 and BMI (β: +0.72 kg/m2 for A minor allele carriers; p = 0.016). In the haplotype analysis, the TA haplotype (carrying the two minor alleles) was associated with both lower sleep duration (Δ = -0.38 h/day; p = 0.05) and higher BMI (Δ = +1.41 kg/m2; p = 0.018) in boys, when compared with the common CC haplotype.

CONCLUSIONS:

The REV-ERBα rs2071427 and rs2071570 were associated with both sleep duration and BMI in boys. These findings confirmed the relevance of the REV-ERBα gene in human obesity, primarily in males, and also suggested that it has a potential role in affecting sleep duration.

KEYWORDS:

Obesity; REV-ERBα clock gene; Sleep duration; Youth

PMID:
29773212
DOI:
10.1016/j.sleep.2018.01.014
[Indexed for MEDLINE]

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