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Nutrients. 2018 May 16;10(5). pii: E624. doi: 10.3390/nu10050624.

Pilot Study Examining the Influence of Potassium Bicarbonate Supplementation on Nitrogen Balance and Whole-Body Ammonia and Urea Turnover Following Short-Term Energy Restriction in Older Men.

Author information

1
Nutrition, Exercise, Physiology, and Sarcopenia Laboratory, United States Department of Agriculture Jean Mayer Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA. lee.margolis@tufts.edu.
2
Bone Metabolism Laboratory, United States Department of Agriculture Jean Mayer Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA. lisa.ceglia@tufts.edu.
3
Division of Endocrinology, Diabetes, and Metabolism, Tufts Medical Center, Boston, MA 02111, USA. lisa.ceglia@tufts.edu.
4
Nutrition, Exercise, Physiology, and Sarcopenia Laboratory, United States Department of Agriculture Jean Mayer Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA. donato.rivas@tufts.edu.
5
Bone Metabolism Laboratory, United States Department of Agriculture Jean Mayer Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA. bess.dawson-hughes@tufts.edu.
6
Nutrition, Exercise, Physiology, and Sarcopenia Laboratory, United States Department of Agriculture Jean Mayer Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA. roger.fielding@tufts.edu.

Abstract

With aging there is a chronic low-grade metabolic-acidosis that may exacerbate negative protein balance during weight loss. The objective of this randomized pilot study was to assess the impact of 90 mmol∙day-1 potassium bicarbonate (KHCO₃) versus a placebo (PLA) on 24-h urinary net acid excretion (NAE), nitrogen balance (NBAL), and whole-body ammonia and urea turnover following short-term diet-induced weight loss. Sixteen (KHCO₃; n = 8, PLA; n = 8) older (64 ± 4 years) overweight (BMI: 28.5 ± 2.1 kg∙day-1) men completed a 35-day controlled feeding study, with a 7-day weight-maintenance phase followed by a 28-day 30% energy-restriction phase. KHCO₃ or PLA supplementation began during energy restriction. NAE, NBAL, and whole-body ammonia and urea turnover (15N-glycine) were measured at the end of the weight-maintenance and energy-restriction phases. Following energy restriction, NAE was -9.8 ± 27.8 mmol∙day-1 in KHCO₃ and 43.9 ± 27.8 mmol∙day-1 in PLA (p < 0.05). No significant group or time differences were observed in NBAL or ammonia and urea turnover. Ammonia synthesis and breakdown tended (p = 0.09) to be higher in KHCO₃ vs. PLA following energy restriction, and NAE was inversely associated (r = -0.522; p < 0.05) with urea synthesis in all subjects. This pilot study suggests some benefit may exist with KHCO₃ supplementation following energy restriction as lower NAE indicated higher urea synthesis.

KEYWORDS:

acid-base; aging; alkaline supplement; weight loss

PMID:
29772642
PMCID:
PMC5986503
DOI:
10.3390/nu10050624
[Indexed for MEDLINE]
Free PMC Article

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