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Fitoterapia. 2018 Jul;128:130-134. doi: 10.1016/j.fitote.2018.05.004. Epub 2018 May 14.

Four new compounds isolated from Psoralea corylifolia and their diacylglycerol acyltransferase (DGAT) inhibitory activity.

Author information

1
College of Pharmacy, Beihua University, Jilin 132013, China.
2
Molecular Cancer Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 685-1 Yangcheongri, Ochangeup, Cheongwongun, Chungbuk 363-883, Republic of Korea.
3
College of Pharmacy, Beihua University, Jilin 132013, China. Electronic address: cuilong71@beihua.edu.cn.

Abstract

A new bakuchiol compound Δ11-12-hydroxy-12-dimethyl bakuchiol (1), a new flavanone compound 2(S)-6-methoxy-7- hydroxymethylene-4'-hydroxyl-flavanone (8), and two new isoflavanone compounds 4',7-dihydroxy-3'-(6"β-hydroxy-3″,7″-dimethyl-,2″,7″-dibutenyl)-geranylisoflavone (9) and 4',7-dihydroxy-3'-(7″-hydroxy-7″-methyl-2″,5″-dibutenyl)-geranylisoflavone (10) together with eight known compounds (2-7, 11, 12) were isolated from the P. corylifolia. Their structures were elucidated on the basis of spectroscopic and physico-chemical analyses. All the isolates were evaluated for in vitro inhibitory activity against DGAT1/2. Among them, compounds 3, 9 and 10 were found to exhibit selective inhibitory activity on DGAT1 with IC50 values ranging from 93.7 ± 1.3 to 96.2 ± 1.1 μM. Compound 1 showed inhibition activity on DGAT1 with IC50 values 73.4 ± 1.3 μM and inhibition of DGAT2 with IC50 value 121.1 ± 1.3 μM.

KEYWORDS:

Bu-Gu-Zhi; DGAT; Leguminosae; P. corylifolia

PMID:
29772304
DOI:
10.1016/j.fitote.2018.05.004
[Indexed for MEDLINE]

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