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Ophthalmic Surg Lasers Imaging Retina. 2018 May 1;49(5):313-319. doi: 10.3928/23258160-20180501-04.

Endophthalmitis Associated With Intravitreal Injections of Anti-VEGF Agents at a Tertiary Referral Center: In-House and Referred Cases.

Abstract

BACKGROUND AND OBJECTIVE:

To report the incidence rates, causative organisms, and visual acuity (VA) outcomes in patients with endophthalmitis associated with intravitreal injection of anti-vascular endothelial growth factor inhibitors.

PATIENTS AND METHODS:

Retrospective case series between 2005 and 2017.

RESULTS:

The study included 39 eyes of 39 patients, including 27 (69%) referred and 12 (31%) institutional patients. The use of topical antibiotics after an injection was gradually phased out at the authors' institution, where the preinjection rate of all clinically suspected endophthalmitis was 0.013% (24 of 183,898). The most common isolates were coagulase-negative Staphylococcus and Streptococcus. A VA of 5/200 or better was achieved in 21 of 39 eyes (54%) overall and in two of 15 eyes (13%) infected with Streptococcus.

CONCLUSIONS:

The rate of post-intravitreal injection endophthalmitis is low. Outcomes were generally poor, and the worst were associated with Streptococcus. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:313-319.].

PMID:
29772041
DOI:
10.3928/23258160-20180501-04
[Indexed for MEDLINE]

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