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Ocul Immunol Inflamm. 2018 May 17:1-10. doi: 10.1080/09273948.2018.1467464. [Epub ahead of print]

Increased Circulating Proinflammatory T Lymphocytes in Children with Different Forms of Anterior Uveitis: Results from a Pilot Study.

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a Department of Ophthalmology and Ophtha Lab , St. Franziskus-Hospital Muenster , Muenster , Germany.
b Department of Pediatric Rheumatology and Immunology , University Hospital Muenster , Muenster , Germany.
c Department of Ophthalmology , University of Duisburg-Essen , Duisburg , Germany.



To characterize peripheral blood T cells in juvenile idiopathic arthritis-associated uveitis (JIAU).


Blood samples were taken from children with JIAU (n = 18), JIA without ocular involvement (n = 11), idiopathic anterior uveitis (IAU, n = 12), and healthy controls (n = 11). Cells were stained for T cell surface markers, and intracellular cytokine staining was performed after cell stimulation and analyzed by flow cytometry.


The Th1/Th2 ratio was increased in JIAU patients. Numbers of IL-13-expressing cells an level of IL-13 and IL-10 expression per cell were increased in all patient groups; whereas, percentages of IL-5-expressing T cells were decreased. Numbers of proinflammatory Th17 cells and T cells expressing CTLA-4 were increased in all patient groups; whereas, γ/δ T cell numbers were decreased. Results from JIA and IAU were similar.


T cell subtypes and potential T cell function are altered in pediatric patients with uveitis and arthritis as compared to healthy children.


Juvenile arthritis; PBMC; T cells; Th17; methotrexate; pathogenesis; therapy; uveitis

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