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Clin Infect Dis. 2018 Oct 30;67(10):1617-1620. doi: 10.1093/cid/ciy405.

Effect of Antiretroviral Therapy on Plasma Concentrations of Chloroquine and Desethyl-chloroquine.

Author information

1
Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
2
Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
3
Malaria Research Institute, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.
4
Center for Translational AIDS Research, Departments of Medicine and Neuroscience, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania.
5
Division of Infectious Disease, Department of Medicine, Case Western Reserve University, Cleveland, Ohio.
6
Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.
7
Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom.

Abstract

The effect of antiretroviral therapy (ART) on chloroquine and desethyl-chloroquine plasma concentrations was evaluated in clinical trial participants. Concentrations did not differ among participants receiving protease inhibitor-based ART (n = 9), efavirenz-based ART (n = 15), or other ART (n = 8) and those not receiving ART (n = 31). Efavirenz seemed to inhibit chloroquine desethylation.

PMID:
29771277
PMCID:
PMC6206114
[Available on 2019-10-30]
DOI:
10.1093/cid/ciy405

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