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Future Microbiol. 2018 Jun 1;13:737-744. doi: 10.2217/fmb-2017-0286. Epub 2018 May 17.

Nature-derived microbiota exposure as a novel immunomodulatory approach.

Author information

1
Department of Virology, Faculty of Medicine & Life Sciences, University of Tampere, Arvo Ylpön katu 34, 33520 Tampere, Finland.
2
Computational Biology, Faculty of Medicine & Life Sciences, University of Tampere, Arvo Ylpön katu 34, 33520 Tampere, Finland.
3
Ecosystems and Environment Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Niemenkatu 73, 15140 Lahti, Finland.
4
Department of Pediatrics, 2nd Faculty of Medicine, Charles University & University Hospital Motol, V Úvalu 84, Praha 5, 150 06 Prague, Czech Republic.
5
Department of Internal Medicine, Tampere University Hospital, Teiskontie 35, 33520 Tampere, Finland.
6
Fimlab Laboratories, Pirkanmaa Hospital District, Arvo Ylpön katu 4, 33520 Tampere, Finland.

Abstract

AIM:

Current attempts to modulate the human microbiota and immune responses are based on probiotics or human-derived bacterial transplants. We investigated microbial modulation by soil and plant-based material.

MATERIALS & METHODS:

We performed a pilot study in which healthy adults were exposed to the varied microbial community of a soil- and plant-based material.

RESULTS:

The method was safe and feasible; exposure was associated with an increase in gut microbial diversity.

CONCLUSION:

If these findings are reproduced in larger studies nature-derived microbial exposure strategies could be further developed for testing their efficacy in the treatment and prevention of immune-mediated diseases.

KEYWORDS:

16s rRNA; biodiversity hypothesis; immune modulation; immune-mediated diseases; microbial diversity; microbiome

PMID:
29771153
DOI:
10.2217/fmb-2017-0286

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