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Early Interv Psychiatry. 2019 Aug;13(4):848-852. doi: 10.1111/eip.12678. Epub 2018 May 17.

Frontal cortical thickness correlates positively with impulsivity in early psychosis male patients.

Author information

1
Department of Psychiatry, Unit for Research in Schizophrenia, Center for Psychiatric Neuroscience, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
2
Department of Psychiatry, Service of General Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
3
Signal Processing Laboratory (LTS5), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
4
Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.
5
Service of Community Psychiatry, Department of Psychiatry, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
6
Department of Psychiatry, Unit for Research in Legal Psychiatry and Psychology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Abstract

AIM:

Impulsive behaviours, which are frequent in young people suffering from psychosis have been linked to risky and violent behaviours and participate to the burden of psychotic illness. Given that morphological brain correlates of impulsivity in schizophrenia have been poorly investigated especially in young adults, the aim of this study was to investigate the relationship between impulsivity and cortical thickness in early psychosis (EP) patients.

METHOD:

A total of 17 male subjects in the early phase of psychosis were recruited. Impulsivity was assessed with the Lecrubier Impulsivity Rating Scale. Mean cortical thickness was extracted from magnetic resonance imaging brain scans, using surface-based methods.

RESULTS:

Mean cortical thickness in the frontal lobe correlated positively with mean impulsivity in EP male patients.

CONCLUSION:

Our results suggest that psychotic subjects exhibiting higher impulsivity have larger frontal cortical thickness, which may pave the way towards the identification of patients with a higher risk to display impulsive behaviours.

KEYWORDS:

cortical thickness; early psychosis; impulsivity; magnetic resonance imaging; violence

PMID:
29770569
DOI:
10.1111/eip.12678

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