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Nature. 2018 May;557(7705):351-358. doi: 10.1038/s41586-018-0088-0. Epub 2018 May 16.

Pancreas regeneration.

Zhou Q1,2, Melton DA3,4,5.

Author information

1
Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. qiao_zhou@harvard.edu.
2
Harvard Stem Cell Institute, Cambridge, MA, USA. qiao_zhou@harvard.edu.
3
Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. dmelton@harvard.edu.
4
Harvard Stem Cell Institute, Cambridge, MA, USA. dmelton@harvard.edu.
5
Howard Hughes Medical Institute, Chevy Chase, MD, USA. dmelton@harvard.edu.

Abstract

The pancreas is made from two distinct components: the exocrine pancreas, a reservoir of digestive enzymes, and the endocrine islets, the source of the vital metabolic hormone insulin. Human islets possess limited regenerative ability; loss of islet β-cells in diseases such as type 1 diabetes requires therapeutic intervention. The leading strategy for restoration of β-cell mass is through the generation and transplantation of new β-cells derived from human pluripotent stem cells. Other approaches include stimulating endogenous β-cell proliferation, reprogramming non-β-cells to β-like cells, and harvesting islets from genetically engineered animals. Together these approaches form a rich pipeline of therapeutic development for pancreatic regeneration.

PMID:
29769672
PMCID:
PMC6168194
DOI:
10.1038/s41586-018-0088-0
[Indexed for MEDLINE]
Free PMC Article

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