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Biosci Rep. 2018 Jun 27;38(3). pii: BSR20180311. doi: 10.1042/BSR20180311. Print 2018 Jun 29.

Synergistic anticancer effects of nanocarrier loaded with berberine and miR-122.

Author information

1
Department of Preventive Dentistry, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin 150001, People's Republic of China.
2
Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin 150001, People's Republic of China.
3
Dental Department, Heilongjiang Electric Power Hospital, Xiangjiang Road, Xiangfang District, Harbin 150030, People's Republic of China.
4
Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, People's Republic of China.
5
Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin 150001, People's Republic of China hao621126@126.com.

Abstract

We introduced polyethyleneimine (PEI)-cholesterol (PC) as a nanocarrier incorporating berberine (BER) and miR-122 for the treatment of oral squamous cell carcinoma (OSCC). BER was stabilized by incorporating PC to form ber-PC. Ber-PC was further electrostatically complexed with miR-122 to yield mr-ber-PC for the co-delivery of BER and miR-122. mr-ber-PC treatment dramatically decreased the level of invasion and migration of OSCC cells compared with single drug treatments. The present study suggested that PC could be a multifunctional nanocarrier for the co-delivery of anticancer drug BER and miR-122 to significantly increase the anticancer therapeutic effects.

KEYWORDS:

OSCC; berberine; miR-122; nanocarrier PC

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