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Immunity. 2018 May 15;48(5):992-1005.e8. doi: 10.1016/j.immuni.2018.04.022.

Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism.

Author information

1
Faculty of Biology and Medicine, University of Lausanne, Service de Pneumologie, CHUV, CLED_02.206, Chemin des Boveresses 155, 1066 Epalinges, Switzerland.
2
Faculty of Biology and Medicine, University of Lausanne, Service de Pneumologie, CHUV, CLED_02.206, Chemin des Boveresses 155, 1066 Epalinges, Switzerland; Global Health Institute, EPFL-SV-GHI Station 19, EPFL, 1015 Lausanne, Switzerland.
3
Faculty of Biology and Medicine, University of Lausanne, Service de Pneumologie, CHUV, CLED_02.206, Chemin des Boveresses 155, 1066 Epalinges, Switzerland; Department of Immunology and Pathology, Monash University, Melbourne, Australia.
4
Department of Physiology, University of Lausanne, 1011 Lausanne, Switzerland; Center for Integrative Genomics (CIG), University of Lausanne, 1015 Lausanne, Switzerland.
5
Faculty of Biology and Medicine, University of Lausanne, Service de Pneumologie, CHUV, CLED_02.206, Chemin des Boveresses 155, 1066 Epalinges, Switzerland; Department of Immunology and Pathology, Monash University, Melbourne, Australia. Electronic address: benjamin.marsland@monash.edu.

Abstract

Dietary fiber protects against chronic inflammatory diseases by dampening immune responses through short-chain fatty acids (SCFAs). Here we examined the effect of dietary fiber in viral infection, where the anti-inflammatory properties of SCFAs in principle could prevent protective immunity. Instead, we found that fermentable dietary fiber increased survival of influenza-infected mice through two complementary mechanisms. High-fiber diet (HFD)-fed mice exhibited altered bone marrow hematopoiesis, characterized by enhanced generation of Ly6c- patrolling monocytes, which led to increased numbers of alternatively activated macrophages with a limited capacity to produce the chemokine CXCL1 in the airways. Blunted CXCL1 production reduced neutrophil recruitment to the airways, thus limiting tissue immunopathology during infection. In parallel, diet-derived SCFAs boosted CD8+ T cell effector function by enhancing cellular metabolism. Hence, dietary fermentable fiber and SCFAs set an immune equilibrium, balancing innate and adaptive immunity so as to promote the resolution of influenza infection while preventing immune-associated pathology.

KEYWORDS:

CD8(+) T cells; SCFA; fiber; hematopoiesis; influenza; metabolism; neutrophils; patrolling monocytes

Comment in

PMID:
29768180
DOI:
10.1016/j.immuni.2018.04.022
[Indexed for MEDLINE]

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