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Biochem Cell Biol. 2018 May 16. doi: 10.1139/bcb-2018-0004. [Epub ahead of print]

mTOR Signalling: Jack-of-All-Trades.

Author information

1
Dalhousie University, Physiology and Biophysics , 5850 College Street , Halifax, Nova Scotia, Canada , B3H 1X5 ; yassine.elhiani@Dal.Ca.
2
Jewish General Hospital and Lady Davis Institute for Medical Research, Montreal, Canada ; egomemmanuel@gmail.com.
3
Dalhousie University, Physiology and Biophysics, Halifax, Nova Scotia, Canada ; xpdong@dal.ca.

Abstract

The mechanistic target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase that senses and integrates environmental information into cellular regulation and homeostasis. Accumulating evidence has suggested a master role of mTOR signaling in many fundamental aspects of cell biology and organismal development. mTOR deregulation is implicated in a broad range of pathological conditions, including diabetes, cancer, neurodegenerative diseases, myopathies, inflammatory, infectious and autoimmune conditions. Here, we review recent advances in our knowledge of mTOR signaling in mammalian physiology. We also discuss the impact of mTOR alteration in human diseases and how targeting mTOR function can treat human diseases.

PMID:
29768134
DOI:
10.1139/bcb-2018-0004

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