Format

Send to

Choose Destination
Cytokine. 2018 Oct;110:174-180. doi: 10.1016/j.cyto.2018.05.006. Epub 2018 May 12.

Salivary fingerprint of simple obesity.

Author information

1
Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, Poznan, Poland.
2
Department of Computer Science and Statistics, Poznan University of Medical Sciences, Poznan, Poland.
3
Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland.
4
Department of Gastroenterology, Nutrition and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.
5
Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland. Electronic address: jwitow@ump.edu.pl.

Abstract

BACKGROUND:

The nature of a link between poor oral health and obesity is not fully understood. It is also unclear if saliva contributes to it and whether the properties of saliva change as a result of an increase in body mass or rather as a consequence of obesity-associated comorbidities. This pilot study was undertaken in an attempt to determine if salivary biomarkers can identify obesity per se.

METHODS:

Whole mixed saliva was analysed for 16 soluble parameters covering 4 categories (inflammation, oxidative stress, endothelial dysfunction, adipokines). In the discovery group, 19 obese and 25 non-obese women matched for age, with similar hygiene habits, with no comorbidities and not taking any medication known to affect saliva secretion were analysed. In the validation group, a cohort of no-preselected 81 individuals (34 obese) were analysed.

RESULTS:

Individuals with obesity had significantly higher salivary concentrations of several cytokines and adipokines, of which TNF-R1, serpin A12 and PAI-1 were identified as parameters discriminating between obese and non-obese subjects with the highest sensitivity and specificity.

CONCLUSIONS:

Obesity per se leads to distinct changes in the concentration of several parameters in saliva. These findings may have diagnostic implications for distinguishing the effects of obesity and obesity-linked comorbidities on oral health.

KEYWORDS:

Biomarkers; Cytokines; Obesity; Oral health; Saliva

PMID:
29763839
DOI:
10.1016/j.cyto.2018.05.006

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center