Format

Send to

Choose Destination
Alzheimers Dement. 2018 Nov;14(11):1406-1415. doi: 10.1016/j.jalz.2018.03.011. Epub 2018 May 12.

Midlife vascular risk factors and midlife cognitive status in relation to prevalence of mild cognitive impairment and dementia in later life: The Atherosclerosis Risk in Communities Study.

Author information

1
Department of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address: knopman@mayo.edu.
2
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
3
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
4
Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
5
Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
6
Division of Public Health Sciences, School of Medicine, Wake Forest University, Winston-Salem, NC, USA.
7
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.

Abstract

INTRODUCTION:

The interplay between midlife vascular risk factors and midlife cognitive function with later life mild cognitive impairment (MCI) and dementia (DEM) is not well understood.

METHODS:

In the Atherosclerosis Risk in Communities Study, cardiovascular risk factors and cognition were assessed in midlife, ages 45-64 years. In 2011-2013, 20-25 years later, all consenting Atherosclerosis Risk in Communities participants underwent a cognitive and neurological evaluation and were given adjudicated diagnoses of cognitively normal, MCI, or DEM.

RESULTS:

In 5995 participants with complete covariate data, midlife diabetes, hypertension, obesity, and hypercholesterolemia were associated with late-life MCI and DEM. Low midlife cognition function was also associated with greater likelihood of late-life MCI or DEM. Both midlife vascular risk factors and midlife cognitive function remained associated with later life MCI or DEM when both were in the model.

DISCUSSION:

Later life MCI and DEM were independently associated with midlife vascular risk factors and midlife cognition.

KEYWORDS:

APOE; Cognition; Dementia; Diabetes; Epidemiology; Hypertension; Mild cognitive impairment; Prevalence

PMID:
29763593
PMCID:
PMC6231996
[Available on 2019-11-01]
DOI:
10.1016/j.jalz.2018.03.011

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center