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Vitamin C (Ascorbic Acid).

Authors

Abdullah M1, Attia FN2.

Source

StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019-.
2019 Feb 19.

Author information

1
Layton Rahmatullah Eye Hospital Lahore
2
Penn State Health Hershey Medical Center

Excerpt

Vitamin C is a water-soluble vitamin, antioxidant, and essential co-factor for collagen biosynthesis, carnitine and catecholamine metabolism, and dietary iron absorption. Humans are unable to synthesize vitamin C, so it is strictly obtained through dietary intake of fruits and vegetables. Citrus fruits, berries, tomatoes, potatoes, and green leafy vegetables are excellent sources of vitamin C. Although most vitamin C is completely absorbed in the small intestine, the percentage of absorbed vitamin C decreases as intraluminal concentrations increase. Proline residues on procollagen require vitamin C for the hydroxylation, making it necessary for the triple-helix formation of mature collagen. The lack of a stable triple-helical structure compromises the integrity of the skin, mucous membranes, blood vessels, and bone. Consequently, a deficiency in vitamin C results in scurvy, which presents with hemorrhage, hyperkeratosis, and hematological abnormalities.[1][2][3][4][5]

Copyright © 2019, StatPearls Publishing LLC.

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