Send to

Choose Destination
Radiology. 2018 Sep;288(3):859-866. doi: 10.1148/radiol.2018172294. Epub 2018 May 15.

CT-based Visual Classification of Emphysema: Association with Mortality in the COPDGene Study.

Author information

From the Department of Radiology (D.A.L., D.N., T.J., S.M.H.), Division of Biostatistics (C.M.M., C.W., D.C.E.), and Department of Medicine (E.A.R., B.J.M., R.P.B., J.D.C.), National Jewish Health, 1400 Jackson St, Denver, CO 80206; Department of Radiology, Columbia University Medical Center, New York, NY (J.H.M.A.); Department of Diagnostic Radiology, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Sorbonne Universités, Paris, France (P.A.G.); Department of Diagnostic and Interventional Radiology, University of Heidelberg, Translational Lung Research Center Heidelberg, Heidelberg, Germany (H.U.K.); Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Mich (M.K.H., J.L.C.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md (T.H.B.); Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colo (J.E.H.); Medical Service, VA Ann Arbor Healthcare System, Ann Arbor, Mich (J.L.C.); and Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass (E.K.S.).


Purpose To determine whether visually assessed patterns of emphysema at CT might provide a simple assessment of mortality risk among cigarette smokers. Materials and Methods Of the first 4000 cigarette smokers consecutively enrolled between 2007 and 2011 in this COPDGene study, 3171 had data available for both visual emphysema CT scores and survival. Each CT scan was retrospectively visually scored by two analysts using the Fleischner Society classification system. Severity of emphysema was also evaluated quantitatively by using percentage lung volume occupied by low-attenuation areas (voxels with attenuation of -950 HU or less) (LAA-950). Median duration of follow-up was 7.4 years. Regression analysis for the relationship between imaging patterns and survival was based on the Cox proportional hazards model, with adjustment for age, race, sex, height, weight, pack-years of cigarette smoking, current smoking status, educational level, LAA-950, and (in a second model) forced expiratory volume in 1 second (FEV1). Results Observer agreement in visual scoring was good (weighted κ values, 0.71-0.80). There were 519 deaths in the study cohort. Compared with subjects who did not have visible emphysema, mortality was greater in those with any grade of emphysema beyond trace (adjusted hazard ratios, 1.7, 2.5, 5.0, and 4.1, respectively, for mild centrilobular emphysema, moderate centrilobular emphysema, confluent emphysema, and advanced destructive emphysema, P < .001). This increased mortality generally persisted after adjusting for LAA-950. Conclusion The visual presence and severity of emphysema is associated with significantly increased mortality risk, independent of the quantitative severity of emphysema. Online supplemental material is available for this article.

[Available on 2019-09-01]
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center