Format

Send to

Choose Destination
J Epidemiol. 2018 May 11. doi: 10.2188/jea.JE20180011. [Epub ahead of print]

Smoking, alcohol consumption, and risks for biliary tract cancer and intrahepatic bile duct cancer.

Author information

1
Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University.
2
Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center.

Abstract

BACKGROUND:

Smoking and alcohol are established risk factors for several types of cancer, but the effects on biliary cancers comprising biliary tract cancer (BTC) and intrahepatic bile duct cancer (IHBDC) have been inconclusive.

METHODS:

In this population-based prospective cohort study in Japan, we investigated the association of smoking and alcohol consumption with the risks of BTC and its subtypes, and IHBDC incidence in men and women. Furthermore, the association of smoking stratified by drinking status was investigated. The hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using the Cox proportional hazard model.

RESULTS:

A total of 48,367 men and 54,776 women aged 40-69 years were enrolled between 1990 and 1994 and followed up for 846,417 person-years in men and 1,021,330 person-years in women until 2012, during which 246 BTC and 80 IHBDC male cases and 227 BTC and 60 IHBDC female cases were identified. In men, smoking was significantly associated with an increased risk of IHBDC (HR = 2.25 [95% CI, 1.19-4.25] for current smokers with ≥30 pack-years), and the risk was enhanced among regular drinkers (HR = 3.48 [95% CI, 1.41-8.61]). A non-significant increase of IHBDC risk associated with alcohol was observed. Neither smoking nor alcohol consumption was associated with BTC risk. In women, the association of smoking and alcohol consumption with IHBDC and BTC was unclear because current smokers and regular drinkers were very few.

CONCLUSION:

Our findings suggest that smoking increases IHBDC risk in men, especially among regular drinkers.

KEYWORDS:

Alcohol consumption; BTC; IHBDC; Smoking

PMID:
29760302
DOI:
10.2188/jea.JE20180011
Free full text

Supplemental Content

Full text links

Icon for J-STAGE, Japan Science and Technology Information Aggregator, Electronic
Loading ...
Support Center