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Cell Immunol. 2018 Nov;333:2-8. doi: 10.1016/j.cellimm.2018.04.010. Epub 2018 Apr 25.

Emerging glycobiology tools: A renaissance in accessibility.

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1
Case Western Reserve University School of Medicine, Department of Pathology, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
2
Case Western Reserve University School of Medicine, Department of Pathology, 10900 Euclid Avenue, Cleveland, OH 44106, USA. Electronic address: brian.cobb@case.edu.

Abstract

The glycobiology of the immune response is a topic that has garnered increased attention due to a number of key discoveries surrounding IgG function, the specificity of some broadly neutralizing anti-HIV antibodies, cancer immunoregulation by galectin molecules and others. This review is the opening article in a Special Edition of Cellular Immunology focused on glycoimmunology, and has the goal of setting the context for these articles by providing a mini-review of how glycans impact immunity. We also focus on some of the technological and methodological advances in the field of glycobiology that are being deployed to lower the barrier of entry into the glycosciences, and to more fully interrogate the glycome and its function.

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