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J Neuroimmunol. 2018 Jul 15;320:76-79. doi: 10.1016/j.jneuroim.2018.05.002. Epub 2018 May 4.

Niacin modulates macrophage polarization in Parkinson's disease.

Author information

1
Charlie Norwood Veteran Affairs Medical Center, Augusta, GA, USA; Department of Physical Therapy, College of Allied Health Sciences, Augusta University Augusta, GA, USA. Electronic address: cwakade@augusta.edu.
2
Department of Physical Therapy, College of Allied Health Sciences, Augusta University Augusta, GA, USA.
3
Department of Oral Biology, Dental College of Georgia, Augusta University, Augusta, GA, USA.
4
Parkinson's Foundation Center of Excellence, Movement Disorders, Program, Department of Neurology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
5
Department of Oral Biology, Dental College of Georgia, Augusta University, Augusta, GA, USA; Department of Neurology, Medical College of Georgia, Augusta University, Augusta, GA, USA. Electronic address: bbaban@augusta.edu.

Abstract

Neuroinflammation remains a central piece in Parkinson's disease (PD) pathophysiology. However, mechanisms by which PD links to the neuroinflammation remain elusive. Here, for the first time, we report that lower dose of niacin in PD patients may affect macrophage polarization from M1 (pro-inflammatory) to M2 (counter-inflammatory) profile through the niacin receptor GPR109A. Skew in the peripheral macrophages were accompanied by improved quality of life assessments in patients. Low dose niacin supplementation may be beneficial in PD, boosting anti-inflammatory processes and suppressing inflammation. Varied niacin dosages for longer durations may further reveal the potential role of anti-inflammatory interventions in PD progression.

KEYWORDS:

GPR109A; Macrophage polarization; Niacin; Parkinson's disease

PMID:
29759143
DOI:
10.1016/j.jneuroim.2018.05.002
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