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Osteoarthritis Cartilage. 2018 Aug;26(8):1038-1044. doi: 10.1016/j.joca.2018.05.002. Epub 2018 May 22.

Prospective associations of C-reactive protein (CRP) levels and CRP genetic risk scores with risk of total knee and hip replacement for osteoarthritis in a diverse cohort.

Author information

1
Division of Epidemiology, Department of Family Medicine and Public Health, University of California San Diego School of Medicine, La Jolla, CA, USA. Electronic address: aladdinhs@yahoo.com.
2
VA San Diego Healthcare System/University of California San Diego, La Jolla, CA, USA.
3
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
4
Department of Epidemiology, University of Washington, Seattle, WA, USA.
5
Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Department of Family Medicine, Warren Alpert Medical School, Brown University, Providence, RI, USA.
6
Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
7
Division of Medical Dietetics and Health Sciences, School of Health and Rehabilitation Sciences, College of Medicine, The Ohio State University, Columbus, OH, USA.
8
Division of Epidemiology, Department of Family Medicine and Public Health, University of California San Diego School of Medicine, La Jolla, CA, USA.

Abstract

OBJECTIVE:

To examine associations of high-sensitivity C-reactive protein (CRP) levels and polygenic CRP genetic risk scores (GRS) with risk of end-stage hip or knee osteoarthritis (OA), defined as incident total hip (THR) or knee replacement (TKR) for OA.

DESIGN:

This study included a cohort of postmenopausal white, African American, and Hispanic women from the Women's Health Initiative. Women were followed from baseline to date of THR or TKR, death, or December 31, 2014. Medicare claims data identified THR and TKR. Hs-CRP and genotyping data were collected at baseline. Three CRP GRS were constructed: 1) a 4-SNP GRS comprised of genetic variants representing variation in the CRP gene among European populations; 2) a multilocus 18-SNP GRS of genetic variants significantly associated with CRP levels in a meta-analysis of genome-wide association studies; and 3) a 5-SNP GRS of genetic variants significantly associated with CRP levels among African American women.

RESULTS:

In analyses conducted separately among each race and ethnic group, there were no significant associations of ln hs-CRP with risk of THR or TKR, after adjusting for age, body mass index, lifestyle characteristics, chronic diseases, hormone therapy use, and non-steroidal anti-inflammatory drug use. CRP GRS were not associated with risk of THR or TKR in any ethnic group.

CONCLUSIONS:

Serum levels of ln hs-CRP and genetically-predicted CRP levels were not associated with risk of THR or TKR for OA among a diverse cohort of women.

KEYWORDS:

C-reactive protein; CRP; Genetic risk score; Inflammation; Osteoarthritis

PMID:
29758352
PMCID:
PMC6050083
DOI:
10.1016/j.joca.2018.05.002
[Indexed for MEDLINE]
Free PMC Article

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