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Molecules. 2018 May 14;23(5). pii: E1170. doi: 10.3390/molecules23051170.

A Review: The Bioactivities and Pharmacological Applications of Polygonatum sibiricum polysaccharides.

Author information

1
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China. 13553159162@163.com.
2
School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China. wsy0534@126.com.
3
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China. 13553158985@163.com.
4
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China. m13589080261@163.com.
5
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China. yjli_0531@163.com.
6
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China. xfx18364164925@163.com.
7
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China. 18364166659@163.com.
8
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China. 18364167331@163.com.
9
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China. cch@sdutcm.edu.cn.

Abstract

Traditional Chinese Medicine (TCM) has been widely used in China and is regarded as the most important therapeutic. Polygonatum sibiricum (PS), a natural plant used in traditional Chinese medicine, has various functions associated with a number of its components. There are many compositions in PS including polysaccharides, steroids, anthraquinone, alkaloids, cardiac glycosides, lignin, vitamins, various acids, and so on. Of these, polysaccharides play a significant role in PS-based therapeutics. This article summarizes Polygonatum sibiricum polysaccharides (PSP) have many pharmacological applications and biological activities, such as their antioxidant activity, anti-aging activity, an anti-fatigue effect, immunity enhancement effect, antibacterial effect, anti-inflammatory effect, hypolipidemic and antiatherosclerotic effects, anti-osteoporosis effect, liver protection, treatment of diabetes mellitus (DM), anti-cancer effect, and may help prevent Alzheimer's disease, and so on. This review summarized the extraction method, purification method, compositions, pharmacological applications, biological activities, biosynthesis, and prospects of PSP, providing a basis for further study of PS and PSP.

KEYWORDS:

Polygonatum sibiricum polysaccharides (PSP); biological activity; biosythesis; compositions; pharmacological applications; prospects

PMID:
29757991
PMCID:
PMC6099637
DOI:
10.3390/molecules23051170
[Indexed for MEDLINE]
Free PMC Article

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