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Eur J Cardiothorac Surg. 2018 Jul 1;54(1):4-9. doi: 10.1093/ejcts/ezy169.

Statistical primer: sample size and power calculations-why, when and how?

Author information

1
Department of Biostatistics, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
2
Department of Academic Surgery, University of Manchester, Manchester, UK.
3
Department of Cardiothoracic Surgery, James Cook University Hospital, Middlesbrough, UK.
4
Department of Cardiovascular Surgery, University Heart Centre, Freiburg, Germany.

Abstract

When designing a clinical study, a fundamental aspect is the sample size. In this article, we describe the rationale for sample size calculations, when it should be calculated and describe the components necessary to calculate it. For simple studies, standard formulae can be used; however, for more advanced studies, it is generally necessary to use specialized statistical software programs and consult a biostatistician. Sample size calculations for non-randomized studies are also discussed and two clinical examples are used for illustration.

PMID:
29757369
PMCID:
PMC6005113
DOI:
10.1093/ejcts/ezy169
[Indexed for MEDLINE]
Free PMC Article

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