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Endocrinology. 2018 Jul 1;159(7):2545-2553. doi: 10.1210/en.2018-00371.

Multifaceted Roles of Beige Fat in Energy Homeostasis Beyond UCP1.

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Diabetes Center, University of California, San Francisco, San Francisco, California.
Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, San Francisco, California.
Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, California.


Beige adipocytes are an inducible form of thermogenic adipose cells that emerge within the white adipose tissue in response to a variety of environmental stimuli, such as chronic cold acclimation. Similar to brown adipocytes that reside in brown adipose tissue depots, beige adipocytes are also thermogenic; however, beige adipocytes possess unique, distinguishing characteristics in their developmental regulation and biological function. This review highlights recent advances in our understanding of beige adipocytes, focusing on the diverse roles of beige fat in the regulation of energy homeostasis that are independent of the canonical thermogenic pathway via uncoupling protein 1.

[Indexed for MEDLINE]

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