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Head Neck. 2018 Jul;40(7):1400-1405. doi: 10.1002/hed.25119. Epub 2018 May 13.

Topical superoxide dismutase in posttreatment fibrosis in patients with head and neck cancer.

Author information

1
Vanderbilt University Medical Center Department of Otolaryngology - Head and Neck Surgery (PGY-1), Nashville, Tennessee.
2
Department of Otolaryngology - Head and Neck Surgery, Sanford University of South Dakota Medical Center, Sanford Research, Sioux Falls, South Dakota.

Abstract

BACKGROUND:

Topical superoxide dismutase (SOD) has been shown to decrease postradiation fibrosis in some cancers but has not demonstrated an effect in patients with head and neck cancer. The purpose of this study was to determine if topical SOD is an effective treatment for postradiation neck fibrosis.

METHODS:

This was a randomized prospective blinded clinical study of topical SOD versus placebo for the treatment of neck fibrosis. Measures of fibrosis grade and quality of life were obtained at baseline and after 3 months of treatment.

RESULTS:

Improvement in fibrosis score was comparable between the 2 study arms at 3 months.

CONCLUSION:

Both study groups showed improvement but the differences between groups was not statistically significant. Topical SOD likely has limited benefit for posttreatment neck fibrosis but this study confirms other published evidence of benefit from active physical therapy of posttreatment fibrosis in patients with head and neck cancer.

KEYWORDS:

fibrosis; head and neck cancer; quality of life; radiation; superoxide dismutase

PMID:
29756397
DOI:
10.1002/hed.25119

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