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Mediterr J Hematol Infect Dis. 2018 May 1;10(1):e2018035. doi: 10.4084/MJHID.2018.035. eCollection 2018.

Lymphoproliferative Syndromes Associated with Human Herpesvirus-6A and Human Herpesvirus-6B.

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HHV-6 Foundation, Santa Barbara, California, USA.
Department of Pathology and Laboratory Medicine, University of Texas, Houston, Texas, USA.
Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy.


Human herpesvirus 6A and 6B (HHV-6A and HHV-6B) have been noted since their discovery for their T-lymphotropism. Although it has proven difficult to determine the extent to which HHV-6A and HHV-6B are involved in the pathogenesis of many diseases, evidence suggests that primary infection and reactivation of both viruses may induce or contribute to the progression of several lymphoproliferative disorders, ranging from benign to malignant and including infectious mononucleosis-like illness, drug induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS), and nodular sclerosis Hodgkin's lymphoma. Herein, we discuss the conditions associated with the lymphoproliferative capacity of HHV-6, as well as the potential mechanisms behind them. Continued exploration on this topic may add to our understanding of the interactions between HHV-6 and the immune system and may open the doors to more accurate diagnosis and treatment of certain lymphoproliferative disorders.


HHV-6A; HHV-6B; Human herpesvirus; Lymphoproliferative Disease

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Competing interests: The authors have declared that no competing interests exist.

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