Send to

Choose Destination
Iran J Pharm Res. 2018 Winter;17(1):249-260.

Defensive Properties of Ginsenoside Re against UV-B-Induced Oxidative Stress through Up-Regulating Glutathione and Superoxide Dismutase in HaCaT Keratinocytes.

Author information

Research and Development Center, Cosmocos Corporation, Incheon 21698, Korea.
Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon 24341, Korea.
Department of Biological Sciences, College of Natural Sciences, Kangwon National University, Chuncheon 24341, Korea.


Ginseng is now used worldwide as a traditional Oriental medicine. Ginsenosides, also known as ginseng saponins, are responsible for most pharmacological efficacies of ginseng. This work aimed to assess the novel skin anti-photoaging potential of ginsenoside Re (Re), a protopanaxatriol-type ginsenoside, by analyzing reactive oxygen species (ROS), pro-matrix metalloproteinase-2 (proMMP-2) and -9 (proMMP-9), total glutathione (GSH), superoxide dismutase (SOD), and cellular viability in UV-B-irradiated HaCaT keratinocytes. When HaCaT cells were pretreated with Re prior to UV-B irradiation, Re significantly suppressed the UV-B-induced ROS elevation. It was also able to attenuate the UV-B-induced proMMP-2 and -9 elevations at both activity and protein levels. Re was capable of overcoming the UV-B-reduced total GSH content and SOD activity in concentration-dependent ways. Under the experimental conditions used, Re could interfere with cellular viabilities in neither non-irradiated nor UV-B-irradiated keratinocytes.


Ginsenoside Re; Glutathione; Matrix metalloproteinase; Reactive oxygen species; Superoxide dismutase; UV-B-irradiated HaCaT


Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center