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Front Neurosci. 2018 Apr 26;12:273. doi: 10.3389/fnins.2018.00273. eCollection 2018.

Non-invasive Investigation of Human Hippocampal Rhythms Using Magnetoencephalography: A Review.

Author information

1
ARC Centre of Excellence in Cognition and its Disorders, Macquarie University, Sydney, NSW, Australia.
2
Department of Cognitive Science, Macquarie University, Sydney, NSW, Australia.
3
Program in Neurosciences and Mental Health, Hospital for Sick Children Research Institute, Toronto, ON, Canada.
4
Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.
5
Brain and Psychological Sciences Research Centre, Swinburne University of Technology, Melbourne, VIC, Australia.

Abstract

Hippocampal rhythms are believed to support crucial cognitive processes including memory, navigation, and language. Due to the location of the hippocampus deep in the brain, studying hippocampal rhythms using non-invasive magnetoencephalography (MEG) recordings has generally been assumed to be methodologically challenging. However, with the advent of whole-head MEG systems in the 1990s and development of advanced source localization techniques, simulation and empirical studies have provided evidence that human hippocampal signals can be sensed by MEG and reliably reconstructed by source localization algorithms. This paper systematically reviews simulation studies and empirical evidence of the current capacities and limitations of MEG "deep source imaging" of the human hippocampus. Overall, these studies confirm that MEG provides a unique avenue to investigate human hippocampal rhythms in cognition, and can bridge the gap between animal studies and human hippocampal research, as well as elucidate the functional role and the behavioral correlates of human hippocampal oscillations.

KEYWORDS:

deep source imaging; hippocampus; magnetoencephalography (MEG); review; simulation and empirical evidence

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