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Am J Chin Med. 2018;46(4):911-922. doi: 10.1142/S0192415X18500489. Epub 2018 May 13.

Hirsutella sinensis Inhibits Lewis Lung Cancer via Tumor Microenvironment Effector T Cells in Mice.

Author information

1
* Center Laboratory, Affiliated Secondary Hospital, Zhejiang Chinese Medical University, Hangzhou 310053, P. R. China.
2
‡ College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, P. R. China.
3
¶ Department of Breast Surgery, Huzhou Central Hospital, Huzhou 313003, P. R. China.
4
† Institute of Comparative Medicine & Experimental Animal Research Center, Zhejiang Chinese Medical University, Hangzhou 310053, P. R. China.
5
§ Zhejiang Hospital, Hangzhou 310013, P. R. China.
6
∥ Huzhou Hospital of Traditional Chinese Medicine, Affiliated Zhejiang Chinese Medical University, Huzhou 313003, P. R. China.

Abstract

Hirsutella sinensis fungus (HSF) is an artificial substitute of the well-known medicine Cordyceps sinensis with similar beneficial effects in humans. We previously found that HSF can regulate immune function and inhibit tumor growth; however, the mechanisms involved in these effects were still unclear. Accordingly, in this study, we investigated the effects of HSF on immune cell subsets in the tumor microenvironment in mice. The results showed that HSF inhibited Lewis lung cancer growth, alleviated abnormalities in routine blood tests, and enhanced tumor-infiltrating T cells, particularly the proportion of effector CD8[Formula: see text] T cells. In addition, HSF also ameliorated the immune-suppressive microenvironment and decreased the proportions of regulatory T cell and myeloid-derived suppressor cell populations. To confirm the effects of HSF on promotion of effector CD8[Formula: see text] T-cell production, we further evaluated changes in postoperative metastasis following treatment with HSF. Indeed, orthotopic lung metastasis was significantly suppressed, and survival times were increased in HSF-treated mice. Taken together, our findings suggested that HSF inhibited Lewis lung cancer by enhancing the population of effective CD8[Formula: see text] T cells.

KEYWORDS:

Breast Cancer Metastasis; Hirsutella sinensis; Immunotherapy; Orthotopic Mouse Model

PMID:
29754506
DOI:
10.1142/S0192415X18500489
[Indexed for MEDLINE]

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