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Mol Cells. 2018 Jun;41(6):506-514. doi: 10.14348/molcells.2018.2297. Epub 2018 May 10.

Targeting Super-Enhancers for Disease Treatment and Diagnosis.

Author information

1
Department of Biomedical Science and Engineering, Konkuk University, Seoul 05029, Korea.

Abstract

The transcriptional regulation of genes determines the fate of animal cell differentiation and subsequent organ development. With the recent progress in genome-wide technologies, the genomic landscapes of enhancers have been broadly explored in mammalian genomes, which led to the discovery of novel specific subsets of enhancers, termed super-enhancers. Super-enhancers are large clusters of enhancers covering the long region of regulatory DNA and are densely occupied by transcription factors, active histone marks, and co-activators. Accumulating evidence points to the critical role that super-enhancers play in cell type-specific development and differentiation, as well as in the development of various diseases. Here, I provide a comprehensive description of the optimal approach for identifying functional units of super-enhancers and their unique chromatin features in normal development and in diseases, including cancers. I also review the recent updated knowledge on novel approaches of targeting super-enhancers for the treatment of specific diseases, such as small-molecule inhibitors and potential gene therapy. This review will provide perspectives on using super-enhancers as biomarkers to develop novel disease diagnostic tools and establish new directions in clinical therapeutic strategies.

KEYWORDS:

cell identity; clinical therapeutics; disease diagnosis; diseases; super-enhancer

PMID:
29754476
PMCID:
PMC6030247
DOI:
10.14348/molcells.2018.2297
[Indexed for MEDLINE]
Free PMC Article

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