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Environ Pollut. 2018 Sep;240:396-402. doi: 10.1016/j.envpol.2018.04.117. Epub 2018 May 9.

The evaluation of endocrine disrupting effects of tert-butylphenols towards estrogenic receptor α, androgen receptor and thyroid hormone receptor β and aquatic toxicities towards freshwater organisms.

Author information

1
College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China; Guangzhou Key Laboratory of Environmental Exposure and Health, School of Environment, Jinan University, Guangzhou, 510632, China.
2
Zhejiang Province Environmental Monitoring Center, Hangzhou, 310005, China.
3
Shandong Solid Waste and Hazardous Chemicals Pollution Control Center, Ji'nan, 250117, China.
4
College of Environment, Chengdu University of Technology, Chengdu, 610059, China.
5
College of Marine Life Sciences, Ocean University of China, Qingdao, 266003, China.
6
Department of Environmental Engineering, Guangdong University of Petrochemical Technology, Maoming, 525000, China.
7
College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China; Guangzhou Key Laboratory of Environmental Exposure and Health, School of Environment, Jinan University, Guangzhou, 510632, China. Electronic address: shulin@zju.edu.cn.

Abstract

The phenolic compounds have posed public concern for potential threats to human health and ecosystem. Tert-butylphenols (TBPs), as one group of emerging contaminants, showed potential endocrine disrupting effects and aquatic toxicities. In the present study, we detected concentrations of 2,4-DTBP ranging from <0.001 to 0.057 μg/L (detection limit: 0.001 μg/L) in drinking water source from the Qiantang River in East China in April 2016. The endocrine disrupting effects of 2-TBP, 2,4-DTBP and 2,6-DTBP toward human estrogen receptor α (ERα), androgen receptor (AR) and thyroid hormone receptor β (TRβ) were evaluated using human recombinant two-hybrid yeast bioassay. Their aquatic toxicities were investigated with indicator organisms including Photobacterium phosphoreum, Vibrio fischeri and freshwater green alga Chlamydomonas reinhardtii. 2-TBP and 2,4-DTBP exhibited moderate antagonistic effects toward human ERα and AR in a concentration-dependent manner. 2-TBP significantly inhibited the light emission of P. phosphoreum. 2-TBP, 2,4-DTBP and 2,6-DTBP significantly inhibited the growth of C. reinhardtii and reduced the chlorophyll content. Our results suggest the potential adverse effects of TBPs on human health and aquatic organisms. The data will facilitate further risk assessment of TBPs and related contaminants.

KEYWORDS:

Chlorophyll content; Drinking water source; Ecotoxicity; Green algae; Luminescent bacteria; Phenolic compound

PMID:
29753247
DOI:
10.1016/j.envpol.2018.04.117
[Indexed for MEDLINE]

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