Format

Send to

Choose Destination
Curr Opin Struct Biol. 2018 Aug;51:141-148. doi: 10.1016/j.sbi.2018.04.006. Epub 2018 May 10.

Next-generation antibodies for post-translational modifications.

Author information

1
Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY 10016, United States; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, United States. Electronic address: Takamitsu.Hattori@nyumc.org.
2
Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY 10016, United States; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, United States; Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, United States. Electronic address: Shohei.Koide@nyumc.org.

Abstract

Despite increasing demands for antibodies to post-translational modifications (PTMs), fundamental difficulties in molecular recognition of PTMs hinder the generation of highly functional anti-PTM antibodies using conventional methods. Recently, advanced approaches in protein engineering and design that have been established for biologics development were applied to successfully generating highly functional anti-PTM antibodies. Furthermore, structural analyses of anti-PTM antibodies revealed unprecedented binding modes that substantially increased the antigen-binding surface. These features deepen the understanding of mechanisms underlying specific recognition of PTMs, which may lead to more effective approaches for generating anti-PTM antibodies with exquisite specificity and high affinity.

PMID:
29753204
DOI:
10.1016/j.sbi.2018.04.006

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center