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Angew Chem Int Ed Engl. 2018 Jul 2;57(27):8125-8129. doi: 10.1002/anie.201803535. Epub 2018 Jun 6.

Multipronged Biomimetic Approach To Create Optically Tunable Nanoparticles.

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Princess Margaret Cancer Centre, University Health Network, 101 College St., PMCRT 5-354, Toronto, ON, Canada.
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.


Current biomimetics for medical applications use a single biomimetic approach to imitate natural structures, which can be insufficient for reconstructing structurally complex natural systems. Multipronged efforts may resolve these complexities. To achieve interesting nanostructure-driven optical properties, a dual-biomimetic system contained within a single nanoagent was engineered to recapitulate chlorosomes, efficient light-harvesting organelles that have unique dye assemblies and tunable photonic properties. A series of chlorin dyes was synthesized, and these hydrophobic assemblies were stabilized inside a high-density lipoprotein, a second biomimetic that enabled in vivo utility. This system resulted in tunable tumor imaging of intact (photoacoustic) and disrupted (activatable fluorescence) nanostructures. The successful demonstration of this multipronged biomimetic approach opens the door for reconstruction of complex natural systems for biomedical applications.


biomimetics; imaging agents; lipoproteins; nanoparticles; self-assembly

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