Format

Send to

Choose Destination
BMC Urol. 2018 May 11;18(1):40. doi: 10.1186/s12894-018-0358-z.

Primary synovial sarcoma of the kidney: a case report of complete pathological response at a Lebanese tertiary care center.

Author information

1
Department of Internal Medicine, Division of Hematology/Oncology, American University of Beirut - Medical Center, P.o.Box: 11-0236, Riad El Solh, Beirut, 110 72020, Lebanon.
2
Department of Pathology and Laboratory Medicine, American University of Beirut - Medical Center, Beirut, Lebanon.
3
Department of Internal Medicine, Division of Hematology/Oncology, American University of Beirut - Medical Center, P.o.Box: 11-0236, Riad El Solh, Beirut, 110 72020, Lebanon. as04@aub.edu.lb.

Abstract

BACKGROUND:

Primary synovial sarcoma of the kidney is a rare type of soft tissue sarcoma. Its presenting features can resemble those of other renal tumors; rendering its early diagnosis, a dilemma. Several cases of renal synovial sarcoma have been reported in the literature with varying treatment options and outcomes. This article describes a rare case of primary renal synovial sarcoma and reviews all cases in the literature.

CASE PRESENTATION:

A 26-year-old male presented with flank pain and hematuria. Initially diagnosed with Wilm's tumor, revision of pathology and histology, along with the immunohistochemical profile, confirmed, nevertheless, the diagnosis of primary monophasic synovial sarcoma of the kidney with the SYT-SSX2 fusion transcript. Follow-up, post nephrectomy, revealed recurrence within the lungs and at the surgical bed. Surgical resection followed by adjuvant chemotherapy regimen constituting of Doxorubicin and Ifosfamide, achieved complete pathological response.

CONCLUSION:

In this case report, we emphasize the need for accurate diagnosis and prompt treatment. We propose multimodality treatment approach including surgery along with anthracycline-based chemotherapy to induce complete remission.

KEYWORDS:

Doxorubicin; Ifosfamide; Pathological response; SYT-SSX; Survival; Synovial sarcoma

PMID:
29751751
PMCID:
PMC5948733
DOI:
10.1186/s12894-018-0358-z
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center