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Per Med. 2017 Jul;14(4):299-307. doi: 10.2217/pme-2017-0016. Epub 2017 Jun 15.

LEPR gene polymorphism and plasma soluble leptin receptor levels are associated with polycystic ovary syndrome in Han Chinese women.

Tu X1, Yu C1,2, Gao M3,4, Zhang Y1, Zhang Z1, He Y3,4, Yao L3,4, Du J1, Sun Y3,4, Sun Z1.

Author information

1
Key Lab of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200032, China.
2
Institute of Health Inspection, Gui Zhou Provincial Center for Disease Prevention & Control, Guiyang 550001, China.
3
Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135, China.
4
Shanghai Key Laboratory for Assisted Reproduction & Reproductive Genetics, Shanghai 200135, China.

Abstract

AIM:

To investigate the association of LEPR polymorphisms and plasma leptin and soluble leptin receptor (sOB-R) levels with polycystic ovary syndrome (PCOS) in Chinese women.

PATIENTS & METHODS:

LEPR Lys109Arg (rs1137100) and Gln223Arg (rs1137101) polymorphisms of PCOS patients and the controls were genotyped. Plasma leptin and sOB-R levels of two groups were measured.

RESULTS:

The genotypic distributions of Lys109Arg (rs1137100) differed between the PCOS and control groups. Plasma sOB-R levels increased significantly in PCOS patients and were associated with PCOS independent of BMI. Furthermore, luteinizing hormone, triglyceride and fasting blood glucose correlated significantly to PCOS patients' sOB-R levels.

CONCLUSION:

LEPR Lys109Arg (rs1137100) was associated with PCOS susceptibility and genotype AA was deduced to be a protective factor for PCOS; sOB-R levels might be recognized as a new indicator for the severity of PCOS.

KEYWORDS:

association; indicator; leptin; leptin receptor; polycystic ovary syndrome; single nucleotide polymorphisms

PMID:
29749830
DOI:
10.2217/pme-2017-0016
[Indexed for MEDLINE]
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