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Yonsei Med J. 2018 Jun;59(4):495-500. doi: 10.3349/ymj.2018.59.4.495.

Prognostic Value of MicroRNAs in Coronary Artery Diseases: A Meta-Analysis.

Author information

1
BEER, Busan Society of Evidence-based Mdicine and Research, Busan, Korea.
2
Department of Family Medicine, BHS Han Seo Hospital, Busan, Korea.
3
Department of Nuclear Medicine, Pusan National University Hospital, Busan, Korea.
4
Department of Orthopaedic Surgery, Pusan National University Hospital, Busan, Korea.
5
Analytics Group, Deloitte Consulting LLC, Seoul, Korea.
6
Department of Anatomy, School of Medicine, Pusan National University, Yangsan, Korea.
7
Department of Pharmacology, School of Medicine, Pusan National University, Yangsan, Korea.
8
Department of Anatomy, School of Medicine, Pusan National University, Yangsan, Korea. yunhak10510@pusan.ac.kr.

Abstract

PURPOSE:

Coronary artery diseases (CADs) are the leading causes of death in the world. Recent studies have reported that differentially expressed microRNAs (miRNAs) are associated with prognosis or major adverse cardiac events (MACEs) in CAD patients. In a previous meta-analysis, the authors made serious mistakes that we aimed to correct through an updated systematic review and meta-analysis of the prognostic value of altered miRNAs in patients with CADs.

MATERIALS AND METHODS:

We performed a systematic search of MEDLINE (from inception to May 2017) and EMBASE (from inception to May 2017) for English-language publications. Studies of CADs with results on miRNAs that reported survival data or MACEs were included. Data were extracted from each publication independently by two reviewers.

RESULTS:

After reviewing 515 articles, a total eight studies were included in this study. We measured pooled hazard ratios (HRs) and 95% confidence intervals (CIs) of miRNA 133a with a fixed-effect model (pooled HR, 2.35; 95% CI, 1.56-3.55). High expression of miRNA 133a, 208b, 126, 197, 223, and 122-5p were associated with high mortality. Additionally, high levels of miRNA 208b, 499-5p, 134, 328, and 34a were related with MACEs.

CONCLUSION:

The present study confirmed that miRNA 133a, which was associated with high mortality in CAD patients, holds prognostic value in CAD. More importantly, this study corrected issues raised against a prior meta-analysis and provides accurate information.

KEYWORDS:

Coronary artery disease; meta-analysis; microRNA; prognosis

PMID:
29749132
PMCID:
PMC5949291
DOI:
10.3349/ymj.2018.59.4.495
[Indexed for MEDLINE]
Free PMC Article

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