Send to

Choose Destination
J Biophotonics. 2018 Sep;11(9):e201800110. doi: 10.1002/jbio.201800110. Epub 2018 May 30.

Photobiomodulation induces antinociception, recovers structural aspects and regulates mitochondrial homeostasis in peripheral nerve of diabetic mice.

Author information

Laboratory of Neuromodulation of Experimental Pain, Department of Anatomy, University of São Paulo, São Paulo, Brazil.
Laboratory of Ultrastructure of Cells and Tissues, Department of Anatomy, University of São Paulo, São Paulo, Brazil.
Laboratory of Cellular and Tissue Biology, Faculty of Applied Sciences, University of Campinas, Limeira, Brazil.
Univeristy City of São Paulo, Medical School, São Paulo, Brazil.


Diabetic peripheral neuropathy (DPN) is a nervous disorder caused by diabetes mellitus, affecting about 50% of patients in clinical medicine. Chronic pain is one of the major and most unpleasant symptoms developed by those patients, and conventional available treatments for the neuropathy, including the associated pain, are still unsatisfactory and benefit only a small number of patients. Photobiomodulation (PBM) has been gaining clinical acceptance once it is able to promote early nerve regeneration resulting in significant improvement in peripheral nerves disabilities. In this work, the effects of PBM (660 nm, 30 mW, 1.6 J/cm2 , 0.28 cm2 , 15 s in a continuous frequency) on treating DPN-induced pain and nerve damage were evaluated in an experimental model of diabetic-neuropathy induced by streptozotocin in mice. PBM-induced antinociception in neuropathic-pain mice was dependent on central opioids release. After 21 consecutive applications, PBM increased nerve growth factor levels and induced structural recovery increasing mitochondrial content and regulating Parkin in the sciatic nerve of DPN-mice. Taking together, these data provide new insights into the mechanisms involved in the effects of PBM-therapy emphasizing its therapeutic potential in the treatment of DPN.


diabetic neuropathy; mitochondrial homeostasis; pain; photobiomodulation

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center