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Science. 2018 May 11;360(6389):660-663. doi: 10.1126/science.aaf2666.

An anatomic transcriptional atlas of human glioblastoma.

Author information

1
Allen Institute for Brain Science, Seattle, WA 98109, USA. mikeh@alleninstitute.org rbpuchalski@gmail.com nameeta.shah@gmail.com.
2
Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA 98122, USA.
3
Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA 98122, USA. mikeh@alleninstitute.org rbpuchalski@gmail.com nameeta.shah@gmail.com.
4
Mazumdar Shaw Center for Translational Research, Bangalore 560099, India.
5
Allen Institute for Brain Science, Seattle, WA 98109, USA.
6
Radia Inc., Lynnwood, WA 98036, USA.
7
White Marsh Forests, Seattle, WA 98119, USA.
8
Department of Neurosurgery, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.
9
Department of Neurological Surgery, Houston Methodist Hospital and Research Institute, Houston, TX 77030, USA.
10
Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
11
Department of Pathology, Division of Neuropathology, University of Washington School of Medicine, Seattle, WA 98104, USA.
12
Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad 500082, India.
13
Virginia Mason Medical Center, Seattle, WA 98101, USA.
14
Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA.
15
TGen, Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
16
Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA.
17
Department of Neurology, Columbia University, New York, NY 10032, USA.
18
Department of Pathology, Columbia University, New York, NY 10032, USA.
19
CellNetix, Seattle, WA 98122, USA.

Abstract

Glioblastoma is an aggressive brain tumor that carries a poor prognosis. The tumor's molecular and cellular landscapes are complex, and their relationships to histologic features routinely used for diagnosis are unclear. We present the Ivy Glioblastoma Atlas, an anatomically based transcriptional atlas of human glioblastoma that aligns individual histologic features with genomic alterations and gene expression patterns, thus assigning molecular information to the most important morphologic hallmarks of the tumor. The atlas and its clinical and genomic database are freely accessible online data resources that will serve as a valuable platform for future investigations of glioblastoma pathogenesis, diagnosis, and treatment.

PMID:
29748285
DOI:
10.1126/science.aaf2666
[Indexed for MEDLINE]

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