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Cell Immunol. 2018 Aug;330:97-104. doi: 10.1016/j.cellimm.2018.04.009. Epub 2018 Apr 22.

The multifaceted role of the renal mononuclear phagocyte system.

Author information

1
Institute of Experimental Immunology, University Clinic of the Rheinische Friedrich-Wilhelms-Universität, 53127 Bonn, Germany.
2
Institute of Experimental Immunology, University Clinic of the Rheinische Friedrich-Wilhelms-Universität, 53127 Bonn, Germany. Electronic address: ckurts@web.de.
3
Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany. Electronic address: sebastian.braehler@uk-koeln.de.

Abstract

The kidney contains a large and complex network of mononuclear phagocytes, which includes dendritic cells (DCs) and macrophages (MØs). The distinction between these cell types is traditionally based on the expression of molecular markers and morphology. However, several classification systems are used in parallel to identify DCs and MØs, leading to considerable uncertainty about their identity and functional roles. The discovery that a substantial proportion of macrophages in tissues like the kidney are embryonically derived further complicates the situation. Recent studies have used newly identified transcription factors such as ZBTB46 and lineage tracing techniques for classifying mononuclear phagocytes. These approaches have shed new light on the functional specialization of these cells in health and disease, uncovered an influence of the renal microenvironment and revealed considerable cellular plasticity, especially in inflammatory situations. In this review, the current knowledge about the developmental origins and versatile functional roles of DCs and MØs in kidney homeostasis and disease is discussed.

KEYWORDS:

Acute kidney injury; Dendritic cell; Glomerulonephritis; Kidney; Macrophage; Mononuclear phagocyte system; Pyelonephritis; Resident macrophage

PMID:
29748002
DOI:
10.1016/j.cellimm.2018.04.009
[Indexed for MEDLINE]

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