Format

Send to

Choose Destination
Med J Aust. 2018 May 21;208(9):398-403. Epub 2018 May 14.

RedUSe: reducing antipsychotic and benzodiazepine prescribing in residential aged care facilities.

Author information

1
Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, TAS juanita.westbury@utas.edu.au.
2
University of Tasmania, Hobart, TAS.
3
Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, TAS.

Abstract

OBJECTIVE:

To assess the impact of a multi-strategic, interdisciplinary intervention on antipsychotic and benzodiazepine prescribing in residential aged care facilities (RACFs). Design, setting: Prospective, longitudinal intervention in Australian RACFs, April 2014 - March 2016.

PARTICIPANTS:

150 RACFs (with 12 157 residents) comprised the main participant group; two further groups were consultant pharmacists (staff education) and community pharmacies (prescribing data). Data for all RACF residents, excluding residents receiving respite or end-stage palliative care, were included.

INTERVENTION:

A multi-strategic program comprising psychotropic medication audit and feedback, staff education, and interdisciplinary case review at baseline and 3 months; final audit at 6 months.

MAIN OUTCOME MEASURE:

Mean prevalence of regular antipsychotic and benzodiazepine prescribing at baseline, and at 3 and 6 months. Secondary measures: chlorpromazine and diazepam equivalent doses/day/resident; proportions of residents for whom drug was ceased or the dose reduced; prevalence of antidepressant and prn (as required) psychotropic prescribing (to detect any substitution practice).

RESULTS:

During the 6-month intervention, the proportion of residents prescribed antipsychotics declined by 13% (from 21.6% [95% CI, 20.4-22.9%] to 18.9% [95% CI, 17.7-20.1%]), and that of residents regularly prescribed benzodiazepines by 21% (from 22.2% [95% CI, 21.0-23.5%] to 17.6% [95% CI, 16.5-18.7]; each, P < 0.001). Mean chlorpromazine equivalent dose declined from 22.9 mg/resident/day (95% CI, 19.8-26.0) to 20.2 mg/resident/day (95% CI, 17.5-22.9; P < 0.001); mean diazepam equivalent dose declined from 1.4 mg/resident/day (95% CI, 1.3-1.5) to 1.1 mg/resident/day (95% CI, 0.9-1.2; P < 0.001). For 39% of residents prescribed antipsychotics and benzodiazepines at baseline, these agents had been ceased or their doses reduced by 6 months. There was no substitution by sedating antidepressants or prn prescribing of other psychotropic agents.

CONCLUSIONS:

The RedUSe program achieved significant reductions in the proportions of RACF residents prescribed antipsychotics and benzodiazepines.

TRIAL REGISTRATION:

Australian New Zealand Clinical Trials, ACTRN12617001257358.

KEYWORDS:

Anti-anxiety agents; Antipsychotic agents; Dementia; Deprescriptions; Geriatric psychiatry; Health services for the aged; Nursing care; Primary care; Psychopharmacology; Psychotropic drugs; Quality of health care; Sleep aids

PMID:
29747564

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center