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Cell Host Microbe. 2018 May 9;23(5):580-582. doi: 10.1016/j.chom.2018.04.010.

Bacterial Autophagy: How to Take a Complement.

Author information

1
Department of Virology, Division of Medicine, Imperial College London, Norfolk Place, London W2 1 PG, UK; Department of Paediatrics, Division of Medicine, Imperial College London, Norfolk Place, London W2 1 PG, UK. Electronic address: v.sancho-shimizu@imperial.ac.uk.
2
Section of Microbiology, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK; Department of Immunology & Infection, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK. Electronic address: serge.mostowy@lshtm.ac.uk.

Abstract

Complement, a complex system of serum proteins, contributes to host defense through multiple mechanisms. In this issue of Cell Host & Microbe, Sorbara et al. (2018) discovered that cytosolic pathogens opsonized by complement are restricted by autophagy. This unexpected role for complement is important for cell-autonomous immunity in the intestinal mucosa.

PMID:
29746830
DOI:
10.1016/j.chom.2018.04.010
[Indexed for MEDLINE]

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