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Int J Gynaecol Obstet. 2018 Aug;142(2):162-169. doi: 10.1002/ijgo.12527. Epub 2018 May 31.

Evaluation of biochemical, endocrine, and metabolic biomarkers for the early diagnosis of polycystic ovary syndrome among non-obese Saudi women.

Author information

1
Zoology Department, Science College, King Saud University, Riyadh, Saudi Arabia.
2
Central Laboratory, Center for Female Scientific and Medical Colleges, King Saud University, Riyadh, Saudi Arabia.

Abstract

OBJECTIVE:

To investigate the potential of selected biochemical, endocrine, and metabolic biomarkers for early diagnosis of polycystic ovary syndrome (PCOS) among non-obese women.

METHODS:

A prospective observational cross-sectional study was conducted at three medical centers in Makkah, Saudi Arabia, between July 15 and September 20, 2017. Eligible participants were non-obese women diagnosed with PCOS according to the Rotterdam criteria (n=44) and non-obese normo-ovulatory women without signs of PCOS (control group; n=44). Anthropometric variables related to metabolic profile were determined. Laboratory measures were assessed using fasting blood samples.

RESULTS:

Waist circumference and waist-to-hip ratio were increased among women with PCOS (both P˂0.001). When compared with the control group, patients in the PCOS group exhibited increases in cholesterol (13.8%), triglycerides (36.6%), low-density lipoprotein (73.2%), fasting glucose (9.2%), fasting insulin (49.4%), luteinizing-hormone/follicle-stimulating-hormone ratio (205.3%), 17β-estradiol (39.2%), testosterone (202.3%), and vascular endothelial growth factor (241.7%) (all P<0.001); and decreases in high-density lipoprotein (-25.3%), progesterone (-7.4%), and sex hormone-binding globulin (-54.0%) (all P<0.001). Vitamin D (P=0.095) and Kisspeptin (P=0.944) levels did not differ between the groups.

CONCLUSION:

Various parameters could potentially be used as biomarkers to assess risk of PCOS, even among symptom-free non-obese women.

KEYWORDS:

Estrogen; Kisspeptin; Lipid profile; Non-obese; Polycystic ovary syndrome; Vascular endothelial growth factor; Vitamin D

PMID:
29745981
DOI:
10.1002/ijgo.12527
[Indexed for MEDLINE]

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