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Bioact Mater. 2017 Apr 25;2(3):138-145. doi: 10.1016/j.bioactmat.2017.04.003. eCollection 2017 Sep.

3D additive-manufactured nanocomposite magnetic scaffolds: Effect of the application mode of a time-dependent magnetic field on hMSCs behavior.

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Institute of Polymers, Composites and Biomaterials, National Research Council, Naples, Italy.
Villa Betania Evangelical Hospital, Naples, Italy.
Department of Neuroscience, Reproductive Sciences and Oral Sciences, University of Naples Federico II, Naples, Italy.
Unit of Dentistry, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.


Over the past few years, the influence of static or dynamic magnetic fields on biological systems has become a topic of considerable interest. Magnetism has recently been implicated to play significant roles in the regulation of cell responses and, for this reason, it is revolutionizing many aspects of healthcare, also suggesting new opportunities in tissue engineering. The aim of the present study was to analyze the effect of the application mode of a time-dependent magnetic field on the behavior of human mesenchymal stem cells (hMSCs) seeded on 3D additive-manufactured poly(ɛ-caprolactone)/iron-doped hydroxyapatite (PCL/FeHA) nanocomposite scaffolds.


Additive manufacturing; Cell-material interaction; Magnetic field; Scaffold

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